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Islam, M.; Chen, B.; Spraggins, J. M.; Kelly, R. T.; Lao, K. S. Use of Single Cell -Omics Technologies to Study the Gastrointestinal Tract and Diseases, From Single Cell Identities to Patient Features, Gastroenterology, 2020, 159, 453–466.
Williams, S. M.; Liyu, A. V.; Tsai, C.-F.; Moore, R. J.; Orton, D. J.; Chrisler, W. B.; Gaffrey, M. J.; Liu, T.; Smith, R. D.; Kelly, R. T.; Pasa-Tolic, L.; Zhu, Y. Automated coupling of nanodroplet sample preparation with liquid chromatography-mass spectrometry for high throughput single-cell proteomics, Anal. Chem., 2020, 92, 10588-10596.
Xiang, P.; Zhu, Y.; Yang, Y.; Zhao, Z.; Williams, S. M.; Moore, R. J.; Kelly, R. T.; Smith, R. D.; Liu, S. Picoflow Liquid Chromatography-Mass Spectrometry for Ultrasensitive Bottom-up Proteomics Using a 2-µm-i.d. Open Tubular Column, Anal. Chem., 2020, 92, 4711-4715.
Cong, Y.; Liang, Y.; Motamedchaboki, K.; Huguet, R.; Truong, T.; Zhao, R.; Shen, Y.; Lopez-Ferrer, D.; Zhu, Y.; Kelly, R. T. Improved Single Cell Proteome Coverage Using Narrow-Bore Packed NanoLC Columns and Ultrasensitive Mass Spectrometry, Anal. Chem.; 2020, 92, 2665-2671.
Piehowski, P. D.; Zhu, Y.; Bramer, L. M.; Stratton, K. G.; Zhao, R.; Orton, D. J.; Moore, R. J.; Yuan, J.; Mitchell, H. D.; Gao, Y.; Webb-Robertson, B.-J. M.; Dey, S. K.; Kelly, R. T.;* Burnum-Johnson, K. E.* Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution, Nat. Commun., 2020, 11, 8.
Zhu, Y.; Scheibinger, M.; Ellwanger, D. C.; Krey, J. F.; Choi, D.; Kelly, R. T.; Heller, S.; Barr-Gillespie, P. G. Single-Cell Proteomics Reveals Changes in Protein Expression During Hair-Cell Development, eLife, 2019, 8, e50777.
Yang, X.; Parashar, R.; Sund, N. L.; Plymale, A. E.; Scheibe, T. D.; Hu. D.; Kelly, R. T. On Modeling Ensemble Transport of Metal Reducing Motile Bacteria, Sci. Rep., 2019, 9, 14638.
Dou, M.; Clair, G.; Tsai, C.-F.; Xu, K.; Chrisler, W. B.; Sontag, R. L.; Zhao, R.; Moore, R. J.; Liu, T.; Pasa-Tolic, L.; Smith, R. D.; Shi, T.; Adkins, J. N.; Qian, W.-J.; Kelly, R. T.; Ansong, C.; Zhu, Y. High-Throughput Single Cell Proteomics Enabled by Multiplex Isobaric Labeling in a Nanodroplet Sample Preparation Platform. Anal. Chem. 2019, 91, 13119–13127.
Dou, M.; Tsai, C.-F.; Piehowski, P. D.; Wang, Y.; Fillmore, T.; Zhao, R.; Moore, R. J.; Zhang, P.; Qian, W.-J.; Smith, R. D.; Liu, T.; Kelly, R. T.;* Shi, T.; Zhu, Y. Automated Nanoflow Two-Dimensional Reversed-Phase Liquid Chromatography System Enables In-Depth Proteome and Phosphoproteome Profiling of Nanoscale Samples, Anal. Chem., 2019, 91, 9707–9715.
Dou, M.; Chouinard, C. D.; Zhu, Y.; Nagy, G.; Liyu, A. V.; Ibrahim, Y. M.; Smith, R. D.; Kelly, R. T.* Nanowell-Mediated Multidimensional Separations Combining nanoLC with SLIM IM-MS for Rapid, High-Peak-Capacity Proteomic Analyses, Anal. Bioanal. Chem., 2019, 411, 5363–5372 (Paper in Forefront).
Xu, K.; Liang, Y.; Piehowski, P. D.; Dou, M.; Schwarz, K. C.; Zhao, R.; Sontag, R. L.; Moore, R. J.; Zhu, Y.; Kelly, R. T.* Benchtop-Compatible Sample Processing Workflow for Proteome Profiling of <100 Mammalian Cells, Anal. Bioanal. Chem. 2019, 411, 4587–4596 (Paper in Forefront).
Couvillion, S. P.; Zhu, Y.; Nagy, G.; Adkins, J. N.; Ansong, C.; Renslow, R. S.; Piehowski, P. D.; Ibrahim, Y. M.; Kelly, R. T.; Metz, T. O. New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells, Analyst, 2019, 144, 794–807 (review).
Zhu, Y.; Podolak, J.; Zhao, R.; Shukla, A. K.; Moore, R. J.; Thomas, G. V.; Kelly, R. T.* Proteome profiling of 1 to 5 spiked circulating tumor cells isolated from whole blood using immunodensity enrichment, laser capture microdissection, nanodroplet sample processing and ultrasensitive nanoLC-MS, Anal. Chem., 2018, 90, 11756–11759.
Liang, Y.; Zhu, Y. Dou, M.; Xu, K.; Chu, R. K.; Chrisler, W. B.; Zhao, R.; Hixson, K. K.; Kelly, R. T.* Spatially resolved proteome profiling of <200 cells from tomato fruit pericarp by integrating laser-capture microdissection with nanodroplet sample preparation, Anal. Chem., 2018, 90, 11106–11114.
Zhu, Y.; Clair, G.; Chrisler, W. B.; Shen, Y.; Zhao, R.; Shukla, A. K.; Moore, R. J.; Misra, R. S.; Pryhuber, G. S.; Smith, R. D.; Ansong, C.; Kelly, R. T.* Proteomic analysis of single mammalian cells enabled by microfluidic nanodroplet sample preparation and ultrasensitive nanoLC-MS, Angew. Chem. Int. Ed., 2018, 57, 12370-12374.
Zhu, Y.; Dou, M.; Piehowski, P. D.; Liang, Y.; Wang, F.; Chu, R. K.; Chrisler, W. B.; Smith, J. N.; Schwarz, K. N.; Shen, Y.; Shukla, A. K.; Moore, R. J.; Smith, R. D.; Qian, W.-J.; Kelly, R. T.* Spatially resolved proteome mapping of laser capture microdissected tissue with automated sample transfer to nanodroplets, Molecular & Cellular Proteomics, 2018, 17, 1864–1874.
Dou, M.; Zhu, Y.; Liyu, A.; Liang, Y.; Chen, J.; Piehowski, P. D.; Xu, K.; Zhao, R.; Moore, R. J.; Atkinson, M. A.; Mathews, C. E.; Qian, W.-J.; Kelly, R. T.* Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of <1000 mammalian cells, Chem. Sci., 2018, 9, 6944-6951.
Moser, T. H.; Mehta, H.; Park, C.; Kelly, R. T. Shokuhfar, T.; Evans, J. E. The Role of Irradiation History in Liquid Cell Transmission Electron Microscopy, Science Advances, 2018, 4, eaaq1202.
Zhu, Y.; Piehowski, P. D.; Zhao, R.; Chen, J.; Shen, Y.; Moore, R. J.; Shukla, A. K.; Petyuk, V.; Campbell-Thompson, M.; Mathews, C. E.; Smith, R. D.; Qian, W.-J.; Kelly, R. T.* Nanodroplet processing platform for deep and quantitative proteome profiling of 10–100 mammalian cells, Nat. Commun., 2018, 9, 882.
Orton, D. J.; Tfaily, M. M.; Moore, R. J.; LaMarche, B. L.; Zheng, X.; Fillmore, T. L.; Chu, R. K.; Weitz, K. K.; Monroe, M. E.; Kelly, R. T.; Smith, R. D.; Baker, E. S. A Customizable Flow Injection System for Automated, High Throughput and Time Sensitive Ion Mobility Spectrometry and Mass Spectrometry Measurements, Anal. Chem., 2018, 90, 737–744.
Zhu, Y.; Zhao, R.; Piehowski, P. D.; Moore, R. J.; Shen, Y.; Lim, S.; Orphan, V.; Pasa-Tolic, L.; Qian, W.-J.; Smith, R. D.; Kelly, R. T.* Sub-Nanogram Proteomics: Impact of LC Column Selection, MS Instrumentation and Data Analysis Strategy on Proteome Coverage for Trace Samples, Int. J. Mass Spectrom., 2018, 427, 4–10 (featured on cover).
Geng, T.; Smallwood, C. R.; Bredeweg, E. L.; Plymale, A. E.; Baker, S. E.; Evans, J. E.; Kelly, R. T.* Multimodal microfluidic platform for controlled culture and analysis of unicellular organisms, Biomicrofluidics, 2017, 11, 054104.
Jambovane, S. R.; Nune, S. K.; Kelly, R. T.; McGrail, P. B.; Wang, Z; Nandasiri, M. I.; Katipamula, S.; Trader, C. D.; Schaef, H. T. Continuous, One-pot Synthesis and Post-Synthetic Modification of NanoMOFs Using Droplet Nanoreactors, Scientific Reports, 2016, 36657.
Cong, Y.; Katipamula, S.; Trader, C. D.; Orton, D. J.; Geng, T.; Baker, E. S.; Kelly, R. T.* Mass Spectrometry-Based Monitoring of Millisecond Protein-Ligand Binding Dynamics Using an Automated Microfluidic Platform, Lab Chip, 2016, 16, 1544–1548 (featured on back cover).
Mahoney, C. M.; Kelly, R. T.; Alexander, L.; Newburn, M.; Bader, S.; Ewing, R. G.; Fahey, A. J.; Atkinson, D. A.; Beagley, N. Bayesian Integration and Classification of Composition C-4 Explosives Based on Time-of-Flight Secondary Ion Mass Spectrometry and Laser Ablation Inductively Coupled Plasma Mass Spectrometry, Anal. Chem., 2016, 88, 3598–3607.
Cong, Y.; Katipamula, S.; Geng, T.; Prost, S.; Tang, K.; Kelly, R. T.* Electrokinetic Sample Preconcentration and Hydrodynamic Sample Injection for Microchip Electrophoresis Using a Pneumatic Microvalve, Electrophoresis, 2016, 37, 455–462.
Geng, T.; Smallwood, C. R.; Zhu, Y.; Bredeweg, E. L.; Baker, S. E.; Evans, J. E.; Kelly, R. T. Multimodal Microchannel and Nanowell-Based Microfluidic Platforms for Bioimaging, Proceedings of the 10th IEEE International Conference on Nano/Molecular Medicine and Engineering, 2016, 10, 155–158 (conference proceedings).
Geng, T.; Bredeweg, E. L.; Szymanski, C. J.; Liu, B.; Baker, S. E.; Orr, G.; Evans, J. E.; Kelly, R. T.* Compartmentalized Microchannel Array for High-Throughput Analysis of Single Cell Polarized Growth and Dynamics, Sci. Rep., 2015, 5, 16111.
Hutchinson, J. R.; Erikson, R. L.; Sheen, A. M.; Ozanich, R. M.; Kelly, R. T.* Rapid, Sensitive and Field-Portable Detection of Bacillus anthracis Spores Using Simple Microfluidic Device and Smartphone-Based Microscopy, Analyst, 2015, 140, 6269–6276.
Baker, E. S.; Burnum-Johnson K. E.; Ibrahim, Y. M.; Orton, D. J.; Monroe, M. E.; Kelly, R. T.; Moore, R. J.; Théberge, R.; Costello, C. E.; Smith, R. D. Enhancing Bottom-up and Top-down Proteomic Measurements with Ion Mobility Separations Proteomics 2015, 15, 2766–2776.
Karim, A. M.; Al-Hasan, N.; Ivanov, S.; Siefert, S.; Kelly, R. T.; Hallfors, N. G.; Benavidez, A.; Kovarik, L.; Jenkins, A.; Winans, R. E.; Datye, A. K. Synthesis of 1 nm Pd Nanoparticles in a Microfluidic Reactor: Insights from In Situ XAFS and SAXS, J. Phys. Chem. C, 2015, 119, 13257–13267.
Grate, J. W.; Mo, K.-F.; Shin, Y.; Vasdekis, A.; Warner, M. G.; Kelly, R. T.; Orr, G.; Hu, D.; Dehoff, K. J.; Brockman, F. J.; Wilkins, M. J. Alexa Fluor-labeled Fluorescent Cellulose Nanocrystals for Bioimaging Solid Cellulose in Spatially Structured Microenvironments Bioconj. Chem. 2015, 26, 593–601.
Vasdekis, A. E.; Wilkins, M. J.; Grate, J. W.; Kelly, R. T.; Konopka, A. E.; Xantheas, S. S.; Chang, T.-M. Solvent Immersion Imprint Lithography, Lab Chip, 2014, 14, 2072–2080.
Jambovane, S.; Prost, S. A.; Sheen, A. S.; Magnuson, J. K.; Kelly, R. T. On-Demand Serial Dilution using Quantized Nano/Picoliter-Scale Droplets. In Micro Total Analysis Systems 2014, Jacobson, S. C.; Kutter, J. P., Eds. Chemical and Biochemical Microsystems Society: San Diego, CA, 2014; pp. 1247–1249 (conference proceedings).
Cong, Y.; Rausch, S. J.; Geng, T.; Jambovane, S.; Kelly, R. T. Pneumatic Microvalve for Electrokinetic Sample Preconcentration and Capillary Electrophoresis Injection. In Micro Total Analysis Systems 2014, Jacobson, S. C.; Kutter, J. P., Eds. Chemical and Biochemical Microsystems Society: San Diego, CA, 2014; pp. 2560–2561 (conference proceedings).
Grate, J. W.; Zhang, C. Y.; Wilkins, M.; Warner, M. G.; Anheier, N. C.; Suter, J.; Kelly, R.; Oostrom, M. Chemical Sensing and Imaging in Microfluidic Pore Network Structures Relevant to Natural Carbon Cycling and Industrial Carbon Sequestration. Proc. SPIE, 2013, 8725, 872522 (conference proceedings).
Hossain, M.; Kaleta, D. T.; Robinson, E. W.; Liu, T.; Zhao, R.; Page, J. S.; Kelly, R. T.; Moore, R. J.; Tang, K.; Camp, D. G.; Qian, W.-J.; Smith, R. D. Enhanced Sensitivity for Selected Reaction Monitoring Mass Spectrometry-based Targeted Proteomics using a Dual-Stage Electrodynamic Ion Funnel Interface Mol. Cell. Proteomics. 2011, 2011 10: M000062-MCP201 (cover article).
Tang, K.; Page, J. S.; Kelly, R. T.; Marginean, I. Electrospray Ionization in Mass Spectrometry. In Encyclopedia of Spectroscopy and Spectrometry, 2nd Edition. Lindon, J. C.; Tranter, G. E.; Koppenaal D. W., Eds. Academic Press: Oxford, UK, 2010; pp. 467–474 (book chapter).
Livesay, E. A.; Tang, K.; Taylor, B. K.; Buschbach, M. A.; Hopkins, D. F.; LaMarche, B. L.; Zhao, R.; Shen, Y.; Orton, D. J.; Moore, R. J.; Kelly, R. T.; Udseth, H. R.; Smith, R. D. Fully Automated Four-Column Capillary LC–MS System for Maximizing Throughput in Proteomic Analyses Anal. Chem. 2008, 80, 294–302.
Yang, F.; Camp II, D. G.; Gritsenko, M. A.; Luo, Q.; Kelly, R. T.; Clauss, T. R. W.; Brinkley, W. R.; Smith, R. D.; Stenoien, D. L. Identification of a Novel Mitotic Phosphorylation Motif Associated with Protein Localization in the Mitotic Apparatus J. Cell Sci. 2007, 120, 4060–4070.
Peeni, B. A.; Conkey, D. B.; Barber, J. P.; Kelly, R. T.; Lee, M. L.; Woolley, A. T.; Hawkins, A. R. Planar Thin Film Device for Capillary Electrophoresis. Lab Chip, 2005, 5, 501–505.
Kelly, R. T.; Humble, P. H., Lee, M. L.; Woolley, A. T. Phase-Changing Sacrificial Materials for the Fabrication of Microfluidic Analysis Systems in Polymers. In Micro Total Analysis Systems 2005, Jensen, K. V.; Han, J.; Harrison, D. J.; Voldman, J., Eds. Transducer Research Foundation: San Diego, CA, 2005; pp 196–198 (conference proceedings).