Publications

2025

22. Kukoyi, E. O.; Lee, K. W. Characterization of PFAS Binding Effects on Protein Structure Using Collision-Induced Unfolding. Chem. Res. Toxicol. 2025. https://doi.org/10.1021/acs.chemrestox.5c00183.

21. Mane, S. S.; Warner, C. D.; Dearden, D. V.; Lee, K. W. Differentiating Isomeric Urea Derivatives by Cyclic Ion Mobility–Mass Spectrometry, Host–Guest Chemistry, and Tandem Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2025. https://doi.org/10.1021/jasms.5c00062.

20. Mane, S. S.; Cox, E. K.; Warner, C. D.; Dearden, D. V.; Lee, K. W. Cyclic IMS-MS Evidence for Potential Ring Opening in Collisionally Activated Sodiated Cyclodextrins. Int. J. Mass Spectrom. 2025, 117444. https://doi.org/10.1016/j.ijms.2025.117444.

2024

19. Mane, S. S.; Dearden, D. V.; Lee, K. W. Identifying and Quantifying Relative Concentrations of Epimers in Mixtures via Cyclic Ion Mobility Mass Spectrometry: Dexamethasone and Betamethasone as a Case Study. J. Am. Soc. Mass Spectrom. 2024, 35 (10), 2458–2464. https://doi.org/10.1021/jasms.4c00258.

18. Anderson, T. K.; Hoferle, P. J.; Chojnacki, K. J.; Lee, K. W.; Coon, J. J.; Kirchdoerfer, R. N. An Alphacoronavirus Polymerase Structure Reveals Conserved Replication Factor Functions. Nucleic Acids Res. 2024, 52 (10), 5975–5986. https://doi.org/10.1093/nar/gkae153.

17. Peters-Clarke, T. M.; Liang, Y.; Mertz, K. L.; Lee, K. W.; Westphall, M. S.; Hinkle, J. D.; McAlister, G. C.; Syka, J. E. P.; Kelly, R. T.; Coon, J. J. Boosting the Sensitivity of Quantitative Single-Cell Proteomics with Infrared-Tandem Mass Tags. J. Proteome Res. 2024. https://doi.org/10.1021/acs.jproteome.4c00076.

2023

16. Westphall, M. S.; Lee, K. W.; Salome, A. Z.; Coon, J. J.; Grant, T. Mass Spectrometers as cryoEM Grid Preparation Instruments. Curr. Opin. Struct. Biol. 2023, 83, 102699. https://doi.org/10.1016/j.sbi.2023.102699.

15. Westphall, M. S.; Lee, K. W.; Hemme, C.; Salome, A. Z.; Mertz, K.; Grant, T.; Coon, J. J. Cryogenic Soft Landing Improves Structural Preservation of Protein Complexes. Anal. Chem. 2023, 95 (40), 15094–15101. https://doi.org/10.1021/acs.analchem.3c03228.

14. Lee, K. W.; Salome, A. Z.; Westphall, M. S.; Grant, T.; Coon, J. J. Onto Grid Purification and 3D Reconstruction of Protein Complexes Using Matrix-Landing Native Mass Spectrometry. J. Proteome Res. 2023, 22 (3), 851–856. https://doi.org/10.1021/acs.jproteome.2c00595.

2022

13. Salome, A. Z.; Lee, K. W.; Grant, T.; Westphall, M. S.; Coon, J. J. Matrix-Landing Mass Spectrometry for Electron Microscopy Imaging of Native Protein Complexes. Anal. Chem. 2022, 94 (50), 17616–17624. https://doi.org/10.1021/acs.analchem.2c04263.

12. Westphall, M. S.; Lee, K. W.; Salome, A. Z.; Lodge, J. M.; Grant, T.; Coon, J. J. Three-Dimensional Structure Determination of Protein Complexes Using Matrix-Landing Mass Spectrometry. Nat. Commun. 2022, 13 (1), 2276. https://doi.org/10.1038/s41467-022-29964-4.

11. Chao, H.-C.; Lee, K. W.; Shih, M.; McLuckey, S. A. Characterization of Homopolymer Distributions via Direct Infusion ESI-MS/MS Using Wide Mass-to-Charge Windows and Gas-Phase Ion/Ion Reactions. J. Am. Soc. Mass Spectrom. 2022, 33 (4), 704–713. https://doi.org/10.1021/jasms.2c00001.

10. Lee, K. W.; Peters-Clarke, T. M.; Mertz, K. L.; McAlister, G. C.; Syka, J. E. P.; Westphall, M. S.; Coon, J. J. Infrared Photoactivation Boosts Reporter Ion Yield in Isobaric Tagging. Anal. Chem. 2022, 94 (7), 3328–3334. https://doi.org/10.1021/acs.analchem.1c05398.

9. Pitts-McCoy, A. M.; Abdillahi, A. M.; Lee, K. W.; McLuckey, S. A. Multiply Charged Cation Attachment to Facilitate Mass Measurement in Negative-Mode Native Mass Spectrometry. Anal. Chem. 2022, 94 (4), 2220–2226. https://doi.org/10.1021/acs.analchem.1c04875.

2020

8. Abdillahi, A. M.; Lee, K. W.; McLuckey, S. A. Mass Analysis of Macro-Molecular Analytes via Multiply-Charged Ion Attachment. Anal. Chem. 2020, 92 (24), 16301–16306. https://doi.org/10.1021/acs.analchem.0c04335.

7. Lee, K. W.; Harrilal, C. P.; Fu, L.; Eakins, G. S.; McLuckey, S. A. Digital Ion Trap Mass Analysis of High Mass Protein Complexes Using IR Activation Coupled with Ion/Ion Reactions. Int. J. Mass Spectrom. 2020, 458, 116437. https://doi.org/10.1016/j.ijms.2020.116437.

6. Lee, K. W.; Eakins, G. S.; Carlsen, M. S.; McLuckey, S. A. Ion Trap Operational Modes for Ion/Ion Reactions Yielding High Mass-to-Charge Product Ions. Int. J. Mass Spectrom. 2020, 451, 116313. https://doi.org/10.1016/j.ijms.2020.116313.

5. Foreman, D. J.; Bhanot, J. S.; Lee, K. W.; McLuckey, S. A. Valet Parking for Protein Ion Charge State Concentration: Ion/Molecule Reactions in Linear Ion Traps. Anal. Chem. 2020, 92 (7), 5419–5425. https://doi.org/10.1021/acs.analchem.0c00146.

2019

4. Lee, K. W.; Eakins, G. S.; Carlsen, M. S.; McLuckey, S. A. Increasing the Upper Mass/Charge Limit of a Quadrupole Ion Trap for Ion/Ion Reaction Product Analysis via Waveform Switching. J. Am. Soc. Mass Spectrom. 2019, 30 (6), 1126–1132. https://doi.org/10.1007/s13361-019-02156-z.

3. Johnson, J. T.; Lee, K. W.; Bhanot, J. S.; McLuckey, S. A. A Miniaturized Fourier Transform Electrostatic Linear Ion Trap Mass Spectrometer: Mass Range and Resolution. J. Am. Soc. Mass Spectrom. 2019, 30 (4), 588–594. https://doi.org/10.1007/s13361-018-02126-x.

2018

2. Dziekonski, E. T.; Johnson, J. T.; Lee, K. W.; McLuckey, S. A. Determination of Collision Cross Sections Using a Fourier Transform Electrostatic Linear Ion Trap Mass Spectrometer. J. Am. Soc. Mass Spectrom. 2018, 29 (2), 242–250. https://doi.org/10.1007/s13361-017-1720-1.

2017

1. Dziekonski, E. T.; Johnson, J. T.; Lee, K. W.; McLuckey, S. A. Fourier-Transform MS and Closed-Path Multireflection Time-of-Flight MS Using an Electrostatic Linear Ion Trap. Anal. Chem. 2017, 89 (20), 10965–10972. https://doi.org/10.1021/acs.analchem.7b02797.