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Chemistry and Biochemistry Labs
Moody Lab

Publications

Calvopina-Chavez DG, Bursey DM, Tseng YJ, Patil LM, Bewley KD, Bennallack PR, et al. Micrococcin cysteine-to-thiazole conversion through transient interactions between the scaffolding protein TclI and the modification enzymes TclJ and TclN. Applied and Environmental Microbiology. Appl Environ Microbiol. 2024 Jun 18;90(6).

Nawarathnage S, Tseng YJ, Soleimani S, Smith T, Pedroza Romo MJ, Abiodun WO, et al. Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain. Structure. 2023 Dec;31(12):1589-1603.e6.

Gajjar PL, Pedroza Romo MJ, Litchfield CM, Callahan M, Redd N, Nawarathnage S, Soleimani S, Averett J,
Wilson E, Lewis A, Stewart C, Tseng YJ, Doukov T, Lebedev A, Moody JD. Increasing the bulk of the 1TEL–target linker and retaining the 10×His tag in a 1TEL–CMG2-vWa construct improves crystal order and diffraction limits. Acta Crystallogr D Struct Biol. 2023 Oct 1;79(10):925–43.

Moody JD, Hill S, Lundahl M, Saxton AJ, Galambas, AK, Broderick WE, Lawrence CM, Broderick JB. A pyruvate formate-lyase activating enzyme variant computationally engineered for crystallization: Structural insights into S adenosylmethionine binding and reductive cleavage. Journal of Biological Chemistry. 2023 Jun;299(6):104791.

Lin HL, James I, Hyer CD, Haderlie CT, Zackrison MJ, Bateman TM, Berg M, Park JS, Daley SA, Zuniga Pina NR, Tseng YJ, Moody JD, Price JC. Quantifying In Situ Structural Stabilities of Human Blood Plasma Proteins Using a Novel Iodination Protein Stability Assay. J Proteome Res. 2022 Dec 2;21(12):2920–35.

Nawarathnage S, Soleimani S, Mathis MH, Bezzant BD, Ramírez DT, Gajjar P, Bunn DR, Stewart C, Smith T,
Pedroza Romo MJ, Brown S, Doukov T, Moody JD. Crystals of TELSAM-target protein fusions that exhibit minimal crystal contacts and lack direct inter-TELSAM contacts. Open Biol. 2022 Mar 2;12(3).

Walls WG, Moody JD, McDaniel EC, Villanueva M, Shepard EM, Broderick WE, Broderick JB. The B12-independent glycerol dehydratase activating enzyme from Clostridium butyricum cleaves SAM to produce 5´-deoxyadenosine and not 5´-deoxy-5´-(methylthio)adenosine. J Inorg Biochem. 2022 Feb;227:111662.

Chan TY, Egbert CM, Maxson JE, Siddiqui A, Larsen LJ, Kohler K, Balasooriya ER, Pennington KL, Tsang TM, Frey M, Soderblom EJ, Geng H, Müschen M, Forostyan TV, Free S, Mercenne G, Banks CJ, Valdoz J, Whatcott CJ, Foulks JM, Bearss DJ, O'Hare T, Huang DCS, Christensen KA, Moody J, Warner SL, Tyner JW, Andersen JL. TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. Nat Commun. 2021 Sep 9;12(1):5337.

Coates TL, Young N, Jarrett AJ, Morris CJ, Moody JD, Della Corte D, Current computational methods for enzyme design. Modern Physics Letters B. 2021 Mar 30;35(09):2150155.

Ludlam WG, Aoba T, Cuéllar J, Bueno-Carrasco MT, Makaju A, Moody JD, Franklin S, Valpuesta JM, Willardson BM. Molecular architecture of the Bardet–Biedl syndrome protein 2-7-9 subcomplex. Journal of Biological Chemistry. 2019 Nov;294(44):16385–99.

Moody JD, Levy S, Mathieu J, Xing Y, Kim W, Dong C, Tempel W, Robitalle A, Dang LT, Ferreccio A, Detraux D, Sidhu S, Zhu L, Carter L, Xu C Wang Y, Valensisi C, Hawkins D, Min J, Moon R, Orkin SH, Baker D, Ruohola-Baker H. First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor. Proceedings of the National Academy of Sciences. 2017 Sep 19;114(38):10125–30.

Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC. Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signaling. Nature. 2017 May 3;545(7653):234–7.

Swiderski K, Shaffer SA, Gallis B, Odom GL, Arnett AL, Scott Edgar J, Baum DM, Chee A, Naim T, Gregorevic P, Murphy KT, Moody J, Goodlett DR, Lynch GS, Chamberlain JS. Phosphorylation within the cysteine-rich region of dystrophin enhances its association with β-dystroglycan and identifies a potential novel therapeutic target for skeletal muscle wasting. Hum Mol Genet. 2014 Dec 20;23(25):6697–711.

Grange J, Moody JD, Ascione MP, Hansen MD. Zyxin-VASP interactions alter actin regulatory activity in zyxin-VASP complexes. Cell Mol Biol Lett. 2013 Jan 1;18(1):1–10.

Wang L, Althoff EA, Bolduc J, Jiang L, Moody J, Lassila JK, Giger L, Hilvert D, Stoddard B, Baker D. Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. J Mol Biol. 2012 Jan;415(3):615–25.

Moody JD, Grange J, Ascione MP, Boothe D, Bushnell E, Hansen MD. A zyxin head-tail interaction regulates zyxin-VASP complex formation. Biochem Biophys Res Commun. 2009 Jan;378(3):625–8.